Science of Lenire

Understand the Science Behind Lenire

• What is neuromodulation?

  Neuromodulation is a therapeutic treatment which can be used for a wide variety of conditions including pain and depression. It works by alternating nerve activity by delivering a stimulus (such as low levels of electric energy) which then alters or adjusts the activity within the body or the brain to improve the specific health condition. Most recently, neuromodulation has emerged as a potential and promising treatment for the management of tinnitus.

• What is bimodal neuromodulation?

  Bimodal neuromodulation is the stimulation of not one but two nerves at the same time. With Lenire, for example, you have the combination of electrical stimulation via the tongue as well as auditory stimulation via the ear. Research has suggested that the combined stimulation of these two nerves drives stronger adaptive neuroplasticity, which in turn can reduce the brain’s attention and sensitivity to the tinnitus sound to a greater extent than when stimulating only a single nerve at a time.

• What is the advantage of bimodal neuromodulation?

  Various research and clinical studies have shown that the combined stimulation of auditory (via the ear) and somatosensory nerves (via the tongue, for example), such as achieved using the non-invasive Lenire device, is more effective when it comes to inducing the positive neuroplasticity important to ease the tinnitus symptoms than stimulating one input at a time. This serves to counter the unhelpful neuroplasticity that gives rise to tinnitus in the first place.

• How effective is Lenire?

  Lenire has been proven as a safe and effective tinnitus treatment in clinical trials with more than 600 participants.

  • TENT-A1 (Trial 1): This study showed that 86.2% of treatment compliant participants reported an improvement in their THI score after 12 weeks of treatment. 80.1% reporting improvement that sustained for 12 months after treatment.
  • TENT-A2 (Trial 2): 91%of compliant patients had sustained relief from tinnitus that lasted 12-months. The average reduction in tinnitus was 20.3 THI points, equal to a full THI grade.
  • TENT-A3 (Trial 3): Lenire has been proven to be more effective than sound-alone for the majority of people with moderate or worse tinnitus.
  • All Trials: Across all clinical trials, 83% would recommend Lenire to treat tinnitus.

  Lenire also conducted real world trials with more than 200 people. The results of Lenire’s real world trials closely matched clinical trial results.

• Is Lenire better suited for certain types of tinnitus?

  Lenire is recommended for patients with subjective tinnitus (where the sound or ringing sensation is only audible to the person experiencing it, regardless of the type of sound they are hearing).

• What grade is my tinnitus?

  Tinnitus is measured on a scale of 1 – 100 on the Tinnitus Handicap Inventory. The higher your THI score, the more impactful tinnitus is on your life. These are classed in the following categories.

  • 00 – 16: Grade 1 (Slight)
  • 18 – 36: Grade 2 (Mild)
  • 38 – 56: Grade 3 (Moderate)
  • 58 – 76: Grade 4 (Severe)
  • 78 – 100: Grade 5 (Catastrophic)

  Lenire’s second clinical trial demonstrated that our dual mode approach could reduce tinnitus impact by a full grade. For example, reducing tinnitus from Severe to Moderate.